Stereoselective synthesis of amphidinolide T1

Yadav, J. S. ; Suresh Reddy, Ch. (2009) Stereoselective synthesis of amphidinolide T1 Organic Letters, 11 (8). pp. 1705-1708. ISSN 1523-7060

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol9002724

Related URL: http://dx.doi.org/10.1021/ol9002724

Abstract

A highly stereoselective total synthesis of amphidinolide T1 is achieved using Sharpless asymmetric epoxidation, base-induced epoxide opening, radical cyclization, diastereoselective reduction followed by allylation, Evans methylation, base-induced reductive elimination, umpolung reaction, chemoselective oxidation, and regioselective macrolactonization.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:62946
Deposited On:24 Sep 2011 05:00
Last Modified:24 Sep 2011 05:00

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