Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents

Murty, M. S. R. ; Ram, Kesur R. ; Venkateswara Rao, Rayudu ; Yadav, J. S. ; Venkateswara Rao, Janapala ; Cheriyan, Vino T. ; John Anto, Ruby (2010) Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents Medicinal Chemistry Research, 20 (5). pp. 576-586. ISSN 1054-2523

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Official URL: http://www.springerlink.com/content/php758n6015935...

Related URL: http://dx.doi.org/10.1007/s00044-010-9353-y

Abstract

The synthesis and cytotoxic activity studies of a new series of cyclic amine containing benzoxazole and benzoxazolone derivatives are described. The 2-cyclic amine-1,3-benzoxazoles 5a-k, 5-chloro-3-(3-chloropropyl)-1,3-benzoxazol-2(3H)-one 8 and 3-[3-(cyclic amino)propyl]-1,3-benzoxazol-2(3H)-ones 9a-f were synthesized. The newly synthesized compounds with the influence of the presence of cyclic amine moiety in the benzoxazole scaffold have been evaluated with respect to their cytotoxic effect toward four human cancer cell lines. The new compounds were evaluated to see whether substitution at the second and third position of the benzoxazole motif influence their cytotoxic effect toward cancer cells.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Benzoxazole; Cyclic Amine; Alkylation; Zinc; Anticancer; Cell Lines
ID Code:62807
Deposited On:24 Sep 2011 05:01
Last Modified:24 Sep 2011 05:01

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