CsF-Celite catalyzed facile N-alkylation of 2(3H)-benzoxazolones and antimicrobial properties of 2-substituted benzoxazole and 3-substituted-2(3H)-benzoxazolone derivatives

Murty, M. S. R. ; Ram, Kesur R. ; Venkateswara Rao, Rayudu ; Yadav, J. S. ; Murty, U. S. N. ; Pranay Kumar, K. (2010) CsF-Celite catalyzed facile N-alkylation of 2(3H)-benzoxazolones and antimicrobial properties of 2-substituted benzoxazole and 3-substituted-2(3H)-benzoxazolone derivatives Medicinal Chemistry Research, 20 (5). pp. 626-636. ISSN 1054-2523

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Official URL: http://www.springerlink.com/content/r6654126446711...

Related URL: http://dx.doi.org/10.1007/s00044-010-9367-5

Abstract

The synthesis and antimicrobial activity studies of a new series of cyclic amine containing benzoxazoles and benzoxazolone-2(3H)-ones derivatives were described. The alkylation of benzoxazolone was carried out using cesium fluoride-Celite. The newly synthesized compounds with the influence of the induction of the cyclic amine moiety in the benzoxazole scaffold have been evaluated with respect to the antibacterial and antifungal activity. The 2-cyclic amine-1,3-benzoxazoles (5a-l), 5-chloro-3-alkyl substituted-1,3-benzoxazol-2(3H)-ones (8a-f), and 3-[3-(cyclic amine)propyl]-1,3-benzoxazol-2(3H)-ones (9a-f) were synthesized. These derivatives were tested for antibacterial and antifungal activity. Among the compounds tested, 8c and 9f showed moderate to good antibacterial and antifungal activity. Compound 8a showed good antifungal activity.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Benzoxazole; Benzoxazolone; Cyclic Amine; Cesium Fluoride-celite; Antibacterial and Antifungal
ID Code:62806
Deposited On:24 Sep 2011 05:02
Last Modified:24 Sep 2011 05:02

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