Iodotrimethylsilane-accelerated one-pot synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones: a novel procedure for the Biginelli-like cyclocondensation reaction at room temperature

Sabitha, Gowravaram ; Reddy, Kusuma B. ; Srinivas, Rangavajjula ; Yadav, Jillu S. (2005) Iodotrimethylsilane-accelerated one-pot synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones: a novel procedure for the Biginelli-like cyclocondensation reaction at room temperature Helvetica Chimica Acta, 88 (11). pp. 2996-2999. ISSN 0018-019X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/hlca.20...

Related URL: http://dx.doi.org/10.1002/hlca.200590242

Abstract

A novel Biginelli-like cyclocondensation reaction is efficiently catalyzed by iodotrimethylsilane (Me3SiI) in MeCN. The reaction proceeds at room temperature by a three-component one-pot condensation of ketones with aldehydes and urea to afford 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones in good yields.

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