Yadav, J. S. ; Reddy, B. V. S. ; Praveenkumar, S. ; Nagaiah, K. (2005) Indium (III) bromide: a novel and efficient reagent for the rapid synthesis of 1, 5-benzodiazepines under solvent-free conditions Synthesis, 2005 (3). pp. 480-484. ISSN 0039-7881
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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...
Related URL: http://dx.doi.org/10.1055/s-2004-834939
Abstract
o-Phenylenediamines (OPDA) undergo rapid condensation with ketones having hydrogens at the α-position in the presence of 10 mol% indium(III) bromide under extremely mild reaction conditions to afford the corresponding 1,5-benzodiazepines in excellent yields with high selectivity. The remarkable features of this new procedure are high conversions, short reaction times, cleaner reaction profiles, high regioselectivity in the case of unsymmetrical ketones, solvent-free conditions, and simple experimental and work-up procedures. This method works well for both electron-rich as well as electron-deficient o-phenylenediamines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers. |
| Keywords: | Indium; Ketones; Heterocycles; Benzodiazepines; Solvent-free Reaction; Drugs |
| ID Code: | 62742 |
| Deposited On: | 24 Sep 2011 04:49 |
| Last Modified: | 24 Sep 2011 04:49 |
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