Green protocol for the Biginelli three-component reaction: Ag3PW12O40 as a novel, water-tolerant heteropolyacid for the synthesis of 3,4-dihydropyrimidinones

Yadav, Jhillu S. ; Subba Reddy, Basi V. ; Sridhar, Pamu ; Reddy, Joolakanti S. S. ; Nagaiah, Kommu ; Lingaiah, Nakka ; Saiprasad, Potharaja S. (2004) Green protocol for the Biginelli three-component reaction: Ag3PW12O40 as a novel, water-tolerant heteropolyacid for the synthesis of 3,4-dihydropyrimidinones European Journal of Organic Chemistry, 2004 (3). pp. 552-557. ISSN 1434-193X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ejoc.20...

Related URL: http://dx.doi.org/10.1002/ejoc.200300559

Abstract

Biginelli three-component condensation of an aldehyde, β-keto ester, and urea proceeds smoothly on the surface of the silver salt of heteropolyacid (HPA), i.e. Ag3PW12O40, in water to afford the corresponding 3,4-dihydropyrimidinones in high-to-quantitative yields under mild conditions. The heterogeneous solid acid provides ease of separation of the catalyst and isolation of the products. The recovered catalyst can be recycled in subsequent reactions with consistent activity. Compared to the classical Biginelli reaction conditions, this new method has the advantages of improved yields, reusability of the catalyst, an eco-friendly solvent, ease of isolation of products, and simplicity in the experimental procedure.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Heteropolyacid; Multicomponent Reactions; Polyoxometalates; Water Media
ID Code:62738
Deposited On:24 Sep 2011 04:49
Last Modified:24 Sep 2011 04:49

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