Knowledge-based protein modeling

Johnson, Mark S. ; Srinivasan, Narayanaswamy ; Sowdhamini, Ramanathan ; Blundell, Tom L. (1994) Knowledge-based protein modeling Critical Reviews in Biochemistry and Molecular Biology, 29 (1). pp. 1-68. ISSN 1040-9238

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Official URL: http://informahealthcare.com/doi/abs/10.3109/10409...

Related URL: http://dx.doi.org/10.3109/10409239409086797

Abstract

Knowledge, both from the three-dimensional structures of homologous proteins and from the general analysis of protein structure, is of value in modeling a protein of known sequence but unknown structure. While many models are still constructed at least in part by manual methods on graphics devices, automated procedures have come into greater use. These procedures include those that assemble fragments of structure from other known structures and those that derive coordinates for the model from the satisfaction of restraints placed on atomic positions.

Item Type:Article
Source:Copyright of this article belongs to Informa plc.
Keywords:Comparative Modeling; Proteins; Three-Dimensional Structures; Amino Acid Sequences; Structure Analysis; Data Banks; Searching; Alignments
ID Code:62639
Deposited On:22 Sep 2011 02:40
Last Modified:09 Oct 2011 16:43

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