Chandrasekhar, S. ; Ramakrishna Reddy, N. ; Srinivasa Rao, Y. (2006) Synthetic studies on Ecteinascidin-743: synthesis of building blocks through sharpless asymmetric dihydroxylation and aza-Michael reactions Tetrahedron, 62 (51). pp. 12098-12107. ISSN 0040-4020
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tet.2006.09.056
Abstract
A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid Ecteinascidin-743 was accomplished, starting from readily available piperonal, 2-methyl anisole, and veratraldehyde. A combination of Vilsmeier-Haack reaction and Sharpless asymmetric dihydroxylation was employed for the synthesis of building blocks A and B whereas a Heck reaction in PEG-2000 and aza-Michael reactions were employed for the synthesis of building block C.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Ecteinascidin-743; Tetrahydroisoquinolines; Heck Reaction; aza-Michael Reaction; Baeyer-Villiger Reaction |
| ID Code: | 62381 |
| Deposited On: | 22 Sep 2011 03:30 |
| Last Modified: | 22 Sep 2011 03:30 |
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