Microwave-assisted one-pot synthesis of benzo[b][1,4]oxazin-3(4H)-ones via Smiles rearrangement

Zuo, Hua ; Meng, Lijuan ; Ghate, Manjunath ; Hwang, Kyu-Hyeon ; Kweon Cho, Yong ; Chandrasekhar, S. ; Raji Reddy, Ch. ; Shin, Dong-Soo (2008) Microwave-assisted one-pot synthesis of benzo[b][1,4]oxazin-3(4H)-ones via Smiles rearrangement Tetrahedron Letters, 49 (23). pp. 3827-3830. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2008.03.120

Abstract

An efficient method for the synthesis of benzo[b][1,4]oxazin-3(4H)-ones via Smiles rearrangement using a microwave-assisted one-pot, three-step reaction has been developed. Various benzo[b][1,4]oxazin-3(4H)-ones are obtained in good yields (55-86%) from the corresponding substituted 2-chlorophenols and primary amines in short reaction time (18-40 min).

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