Chandrasekhar, S. ; Kiran Babu, G. S. ; Raji Reddy, Ch. (2009) Asymmetric synthesis of aza-diospongin A as an iNOS inducer Tetrahedron: Asymmetry, 20 (19). pp. 2216-2219. ISSN 0957-4166
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tetasy.2009.09.013
Abstract
The synthesis of the aza-analogue of diospongin A is described. The key steps in the synthetic sequence are Mitsunobu inversion, cross olefin metathesis and intramolecular aza-Michael addition reactions. The biological activity of this new analogue was also evaluated in the induction of nitric oxide synthase and was found to be better when compared to its natural counterpart.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 62338 |
| Deposited On: | 22 Sep 2011 03:36 |
| Last Modified: | 22 Sep 2011 03:36 |
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