Single DNA molecule grafting and manipulation using a combined atomic force microscope and an optical tweezer

Shivashankar, G. V. ; Libchaber, A. (1997) Single DNA molecule grafting and manipulation using a combined atomic force microscope and an optical tweezer Applied Physics Letters, 71 (25). pp. 3727-3729. ISSN 0003-6951

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Official URL: http://apl.aip.org/resource/1/applab/v71/i25/p3727...

Related URL: http://dx.doi.org/10.1063/1.120495

Abstract

In this letter, we report on spatially selecting and grafting a DNA-tethered bead to an atomic force microscope (AFM) cantilever, using an optical tweezer. To quantify this technique, we measure force versus extension of a single DNA molecule using AFM. For such studies, we have developed a micromanipulation approach by combining an AFM, an optical tweezer, and visualization setup. The ability to select a single DNA polymer and specifically graft it to a localized position on a substrate opens up new possibilities in biosensors and bioelectronic devices.

Item Type:Article
Source:Copyright of this article belongs to American Institute of Physics.
Keywords:Biomolecular Electronics; DNA; Biosensors; Atomic Force Microscopy; Radiation Pressure
ID Code:62281
Deposited On:20 Sep 2011 09:34
Last Modified:20 Sep 2011 09:34

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