Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts

Sarin, A. ; Conan-Cibotti, M. ; Henkart, P. A. (1995) Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts The Journal of Immunology, 155 (8). pp. 3716-3718. ISSN 0022-1767

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Recombinant TNF and lymphotoxin trigger the apoptotic death of normal mouse and human T lymphocyte blasts in vitro. This cytotoxic effect does not involve the Fas death pathway and differs from the TNF- triggered death of tumor cells in several respects: 1) It is a slower process, requiring 2 to 3 days; 2) it is blocked, rather than enhanced, by cycloheximide; and 3) based on the agonistic effect of anti-TNF receptor Abs, it involves a synergistic effect of both the 55-kDa TNFR1 and the 75-kDa TNFR2, as opposed to the dominance of TNFR1 for tumor cytotoxicity. The TNF-induced death of blasts is potently inhibited by IL-2, as well as by IL-1, IL-4, IFN-γ, and IL-12. Because activated T cells secrete both TNF and LT, these findings reveal a new pathway for Ag-induced down-modulation of T cell responses.

Item Type:Article
Source:Copyright of this article belongs to American Association of Immunologists.
ID Code:62153
Deposited On:19 Sep 2011 11:46
Last Modified:19 Sep 2011 11:46

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