Modulation of tubulin synthesis by tri-iodothyronine in the embryonic chick brain

Chaudhury, Sukanya ; Chaudhury, Leena ; Sarkar, Pranab Kumar (1983) Modulation of tubulin synthesis by tri-iodothyronine in the embryonic chick brain Developmental Brain Research, 9 (3). pp. 291-295. ISSN 0165-3806

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0165-3806(83)90026-3

Abstract

In organ cultures of embryonic chick brain, tri-iodothyronine is shown to elicit an age-dependent stimulation of the synthesis of tubulin. In cultures of brains from 8-day embryos where the response is maximal, a 70-100% increase in the rate of synthesis of tubulin is elicited by T3 within 2 h. The stimulatory response is dose-dependent, requires transcription, and is temporally coincident with the early phase of the normal ontogenic rise in level of tubulin and of intense neuronal differentiation in the embryonic chick brain. The overall results indicate the involvement of T3 in regulating the biogenesis of tubulin in the developing brain.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Thyroid Hormones; Tubulin Biosynthesis; Brain Development
ID Code:61716
Deposited On:15 Sep 2011 12:21
Last Modified:15 Sep 2011 12:21

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