Specific binding of L-triiodothyronine modulates Na+-K+- ATPase activity in adult rat cerebrocortical synaptosomes

Sarkar, Pradip Kumar ; Ray, Arun Kumar (1998) Specific binding of L-triiodothyronine modulates Na+-K+- ATPase activity in adult rat cerebrocortical synaptosomes NeuroReport, 9 (6). pp. 1149-1152. ISSN 0959-4965

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Official URL: http://journals.lww.com/neuroreport/Abstract/1998/...

Abstract

Interactions of L-triiodothyronine (T3) in adult rat cerebrocortical synaptosomes were studied in vitro. Scatchard plot analysis revealed two sets of T3 binding sites. The degree of saturation of T3 binding sites (putative receptor) correlated well with the dose-dependent inhibition of Na+-K+-ATPase activity in synaptosomes. The relative binding affinities and relative inhibition of enzyme activities for different TH analogues were L-T3>T3-amine>TRIAC=L-T4>r-T3>T2 and L-T3>T3-amine>TRIAC>L-T4>r-T3>T2, respectively. The present study demonstrates the nature of inhibition of synaptosomal Na+-K+-ATPase activity may be as a function of T3 occupancy of synaptosomal receptor sites in adult mammalian brain.

Item Type:Article
Source:Copyright of this article belongs to Lippincott Williams and Wilkins.
Keywords:Cerebral Cortex; Na+-K+-ATPase; T3 Binding Sites; Synaptosome; Thyroid Hormone
ID Code:61696
Deposited On:15 Sep 2011 12:24
Last Modified:15 Sep 2011 12:24

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