Hydrocortisone receptors and their nuclear acceptor sites in the developing chick retina

Sarkar, P. K. ; Lydigsen, J. (1976) Hydrocortisone receptors and their nuclear acceptor sites in the developing chick retina Biochemical and Biophysical Research Communications, 72 (3). pp. 1084-1090. ISSN 0006-291X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0006-291X(76)80243-4

Abstract

In the embryonic chick retina, hydrocortisone (HC) elicits an age-dependent induction of glutamine synthetase (GS). Cytoplasmic HC-receptors from retinas of both preinducible (7-day) and inducible (12-day) stages of embryonic development display similar chromatographic and sedimentation properties. Specific, saturable receptor-hydrocortisone (R-HC) acceptor sites are detectable in nuclei from retinas of both stages. The concentration of these sites in the chromatin from 7-day retina is greater than that in the 12-day retina. These results suggest that the development of CS inductibility in the retina is eitehr due to ontogenic changes in the specificity of the receptor-acceptor interaction or due to developmental changes affecting the transcription or translation of GS mRNA.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:61669
Deposited On:15 Sep 2011 12:20
Last Modified:15 Sep 2011 12:20

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