Gratraud, Paul ; Surolia, Namita ; Besra, Gurdyal S. ; Surolia, Avadhesha ; Kremer, Laurent (2008) Antimycobacterial activity and mechanism of action of NAS-91 Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1162-1166. ISSN 0066-4804
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Official URL: http://aac.asm.org/cgi/content/abstract/52/3/1162
Related URL: http://dx.doi.org/10.1128/AAC.00968-07
Abstract
The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Δ 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| ID Code: | 61598 |
| Deposited On: | 15 Sep 2011 12:46 |
| Last Modified: | 03 Oct 2011 14:14 |
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