Surolia, Namita ; Misquith, Sandra (1996) Cell surface receptor directed targeting of toxin to human malaria parasite, Plasmodium falciparum FEBS Letters, 396 (1). pp. 57-61. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(96)01065-4
Abstract
Gelonin (a toxin and type II ribosome inactivating protein) when linked to human transferrin can be targeted to Plasmodium falciparum. The transferrin toxin conjugate is significantly toxic to parasite growth and is 25 times more potent than toxin alone in inhibiting parasite protein synthesis. The mechanism of its entry into the intraerythrocytic parasite is discussed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Plasmodium falciparum; Toxin; Ribosome Inactivating Protein; Gelonin-Transferrin Conjugate; Targeting |
| ID Code: | 61589 |
| Deposited On: | 15 Sep 2011 12:45 |
| Last Modified: | 15 Sep 2011 12:45 |
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