Pandey, Ganesh ; Tiwaria, Shashi Kant ; Singh, Ram Shanker ; Mali, Raghao S. (2001) A short and efficient synthesis of enantiopure (+)-N-Boc-7-azabicyclo[2.2.1]heptan-2-one utilizing an asymmetric desymmetrization protocol: formal total synthesis of (-)-epibatidine Tetrahedron Letters, 42 (23). pp. 3947-3949. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4039(01)00616-5
Abstract
A short and efficient synthesis of optically pure (+)-N-Boc-azabicyclo[2.2.1]hept-2-one (2), a precursor in the synthesis of natural (-)-epibatidine (1), is reported by the asymmetric desymmetrization of meso-N-methoxycarbonyl-2,3-bis(phenylsulfonyl)-7-azabicyclo[2.2.1]hept-2-ene (3).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Asymmetric Desymmetrization; Epibatidine; 7-azabicyclo[2.2.1]heptane |
| ID Code: | 61007 |
| Deposited On: | 13 Sep 2011 11:29 |
| Last Modified: | 13 Sep 2011 11:29 |
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