Narasimha Moorthy, Jarugu ; Singhal, Nidhi (2005) Facile and highly selective conversion of nitriles to amides via indirect acid-catalyzed hydration using TFA or AcOH-H2SO4 Journal of Organic Chemistry, 70 (5). pp. 1926-1929. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo048240a
Related URL: http://dx.doi.org/10.1021/jo048240a
Abstract
Both aliphatic and aromatic nitriles are conveniently and selectively converted in a single step, via an indirect acid-catalyzed hydration, into the corresponding amides in 1-8 h using a TFA-H2SO4 mixture as a reagent system. Although the same reagent did not work for the sterically hindered nitriles such as mesitonitrile, the transformation could be accomplished by changing TFA to AcOH at higher temperatures (>90 °C).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 60747 |
| Deposited On: | 10 Sep 2011 11:39 |
| Last Modified: | 10 Sep 2011 11:39 |
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