LiClO4-catalyzed one-pot synthesis of dihydropyrimidinones: an improved protocol for Biginelli reaction

Yadav, Jhillu S. ; Subba Reddy, Basi V. ; Srinivas, R. ; Venugopal, C. ; Ramalingam, T. (2001) LiClO4-catalyzed one-pot synthesis of dihydropyrimidinones: an improved protocol for Biginelli reaction Synthesis, 2001 (9). pp. 1341-1345. ISSN 0039-7881

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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...

Related URL: http://dx.doi.org/10.1055/s-2001-15229

Abstract

Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, β-keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditions. LiOTf is also found to be an efficient catalyst for the synthesis of dihydropyrimidinones from aldehyde, β-keto ester and urea.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers.
Keywords:Biginelli Reaction; Lithium Perchlorate; Lithium Triflate; Dihydropyrimidinones
ID Code:60434
Deposited On:09 Sep 2011 03:49
Last Modified:09 Sep 2011 03:49

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