Stereoselective total synthesis of (+)-artemisinin

Yadav, J. S. ; Satheesh Babu, R. ; Sabitha, G. (2003) Stereoselective total synthesis of (+)-artemisinin Tetrahedron Letters, 44 (2). pp. 387-389. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0040-4039(02)02500-5

Abstract

The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Artemisinin; Stereoselective; Iodolactone; Tris(trimethylsilyl)silane
ID Code:60401
Deposited On:09 Sep 2011 03:50
Last Modified:09 Sep 2011 03:50

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