HIV-1 integration sites are flanked by potential MARs that alone can act as promoters

Kulkarni, Asavari ; Pavithra, L. ; Rampalli, Shravanti ; Mogare, Devraj ; Babu, Kumar ; Shiekh, Gazalla ; Ghosh, Susmita ; Chattopadhyay, Samit (2004) HIV-1 integration sites are flanked by potential MARs that alone can act as promoters Biochemical and Biophysical Research Communications, 322 (2). pp. 672-677. ISSN 0006-291X

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Matrix attachment regions (MARs) are cis regulatory elements that modulate gene expression in a tissue and cell stage specific manner. Recent reports show that viral integration within the genome takes place at nonrandom active genes. We have checked for the presence of MARs in the vicinity of the reported 524 HIV-1 integration sites. Our studies show that in 92.5% cases, MARs flank the integration sites. Similarly, for adeno-associated virus, two potential MARs were present next to the integration site on the human chromosome. Earlier we have shown that short MAR sequences present upstream of HIV-1 LTR promote processive transcription at a distance. Here, using a well-studied IgH-MAR and another potential MAR from p53 promoter, we demonstrate that MARs alone can act as promoters. Thus, we propose that MAR elements near the HIV-1 integration sites can act as potential promoters, which may facilitate proviral integration and transcription.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:HIV-1 Integration; Matrix Associated Regions; IgH MAR; p53 Promoter; Human Genome Analysis
ID Code:60242
Deposited On:08 Sep 2011 09:36
Last Modified:08 Sep 2011 09:36

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