Motifs in gene transcription regulatory networks

Bose, Indrani ; Ghosh, Bhaswar ; Karmakar, Rajesh (2005) Motifs in gene transcription regulatory networks Physica A: Statistical Mechanics and its Applications, 346 (1-2). pp. 49-57. ISSN 0378-4371

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A brief overview is given of the structure and evolution of gene transcription regulatory networks (GTRNs) of simple organisms like Escherichia coli and yeast Saccharomyces cerevisiae. A prominent motif appearing in the GTRNs is the feed forward loop (FFL). The FFLs have essential functions in gene regulatory processes and it is desirable that the operational noise of a FFL be kept at the minimum for reliability of signal transmission. We calculate the variances around the mean protein levels in the steady states of Type-1 and Type-4 coherent FFLs using a stochastic model of gene expression and the Langevin formalism. The Type-1 FFL is found to be less noisy than the Type-4 FFL. Type-1 FFL motif is more abundant than Type-4 FFL motif in GTRNs. This leads to the conjecture that noise is one of the evolvable traits on which natural selection acts.

Item Type:Article
Source:Copyright of this article belongs to European Physical Society.
Keywords:Gene Transcription Regulatory Network; Stochastic Gene Expression; Feed forward Loop; Noise; Natural Selection
ID Code:5986
Deposited On:19 Oct 2010 09:59
Last Modified:19 Oct 2010 09:59

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