Detection of IgM against hepatitis A virus using tissue culture derived antigen

Chitambar, S. D. ; Arankalle, V. A. ; Banerjee, K. (1991) Detection of IgM against hepatitis A virus using tissue culture derived antigen Indian Journal of Medical Research, 93 . pp. 19-21. ISSN 0019-5340

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Official URL: http://icmr.nic.in/ijmr/ijmr.htm

Abstract

Sera from healthy donors and four groups of subjects with acute viral hepatitis were tested for anti-HAV IgM by ELISA with hepatitis A virus antigen grown in tissue culture. The results were compared with those obtained by formalin inactivated HAV from 'HAVAB-M' test kit (Abbott Laboratories, USA). With both preparations of antigens, sera from healthy donors and patients suffering from acute hepatitis B or non-A, non-B did not show anti-HAV IgM antibodies whereas acute phase sera from hepatitis A patients showed strong reactions indicating the presence of anti-HAV IgM antibodies. The results indicate similarity in the specificity of both preparations of HAV against anti-HAV antibodies and encourage the use of tissue culture derived HAV for serological diagnosis of hepatitis A.

Item Type:Article
Source:Copyright of this article belongs to Indian Council of Medical Research.
ID Code:59807
Deposited On:07 Sep 2011 14:32
Last Modified:07 Sep 2011 14:32

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