Type-IV Indian swine HEV infects rhesus monkeys

Arankalle, V. A. ; Chobe, L. P. ; Chadha, M. S. (2006) Type-IV Indian swine HEV infects rhesus monkeys Journal of Viral Hepatitis, 13 (11). pp. 742-745. ISSN 1352-0504

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...

Related URL: http://dx.doi.org/10.1111/j.1365-2893.2006.00759.x


In contrast to countries reporting zoonotic spread of hepatitis E virus (HEV), distinct genotypes circulate in humans (genotype 1) and pigs (genotype 4) from India indicating rarity of such spread. Pigs were refractory to human HEV. As rhesus is an excellent animal model for human HEV, an attempt was made to infect rhesus monkeys with swine HEV. Experimental infection of both the rhesus monkeys with swine-HEV as evidenced by seroconversion to anti-HEV antibodies and presence of viraemia suggests possibility of human infections or differential susceptibility. Comparison of Open Reading Frame-2 and hypervariable regions of HEV genomes showed identity of swine and monkey-derived HEV.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Hepatitis E; Rhesus Monkeys; Sequence Comparisons; Transmission
ID Code:59767
Deposited On:07 Sep 2011 14:40
Last Modified:07 Sep 2011 14:40

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