Contribution of HEV and HCV in causing fulminant non-A, non-B hepatitis in Western India

Arankalle, V. A. ; Jha, J. ; Favorov, M. O. ; Chaudhari, A. ; Fields, H. A. ; Banerjee, K. (1995) Contribution of HEV and HCV in causing fulminant non-A, non-B hepatitis in Western India Journal of Viral Hepatitis, 2 (4). pp. 189-193. ISSN 1352-0504

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...

Related URL: http://dx.doi.org/10.1111/j.1365-2893.1995.tb00028.x

Abstract

During 1990, 38 patients with fulminant non-A, non-B hepatitis (NANB) died in Government Medical College Hospital, Aurangabad. Serum samples from these patients were tested for antibodies to hepatitis C virus (anti-HCV) and IgM antibodies to hepatitis E virus (IgM-anti-HEV). All samples were also subjected to polymerase chain reaction (PCR) for the detection of HBV DNA, HCV RNA and HEV RNA. None of the patients had circulating anti-HCV antibodies; three had HCV RNA. Based on anti-HEV-IgM positivity 14 patients (37%) could be diagnosed as suffering from hepatitis E. None was positive for HEV RNA. In the absence of serological markers, HBV DNA was present in three cases. None of the HBV DNA positive patients had anti-δ antibodies. Dual infections (HBV with HEV, and HBV with HCV) were seen in two cases. The aetiology of half of the NANB cases could not be assigned to the known hepatitis viruses using current techniques.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Fulminant Hepatitis; HCV; HEV; PCR
ID Code:59758
Deposited On:07 Sep 2011 14:33
Last Modified:07 Sep 2011 14:33

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