Yadav, J. S. ; Subba Reddy, B. V. ; Madhusudhan Reddy, G. ; Rehana Anjum, S. (2009) Cu(OTf)2/Cu-catalyzed four-component reaction: a facile synthesis of α-alkoxytriazoles via click chemistry Tetrahedron Letters, 50 (44). pp. 6029-6031. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2009.08.027
Abstract
Aldehyde, alcohol, azide, and alkyne undergo smooth coupling by means of acetal formation, azidation, and a subsequent 'click reaction' in the presence of copper(II) triflate and copper metal in acetonitrile to furnish α-alkoxy-1,2,3-triazoles in good yields. The method provides a convenient route to prepare a wide range of triazoles in a one-pot operation via a four-component reaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Click Reactions; Hemi-acetal Formation; Azidation; α-alkoxytriazoles |
| ID Code: | 59645 |
| Deposited On: | 07 Sep 2011 05:58 |
| Last Modified: | 07 Sep 2011 05:58 |
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