Application of desymmetrization protocol for the formal total synthesis of emericellamide B

Mohapatra, Debendra K. ; Samad Hossain, Sk. ; Dhara, Santu ; Yadav, J. S. (2010) Application of desymmetrization protocol for the formal total synthesis of emericellamide B Tetrahedron Letters, 51 (23). pp. 3079-3082. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2010.04.015

Abstract

A highly convergent formal total synthesis of emericellamide B, a 19-membered antibacterial depsipeptide is described. The key feature of the strategy is the generation of four stereogenic centers from a bicyclic precursor via desymmetrization technique and utilization for emericellamide B and related natural product synthesis.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Emericellamide B; Cytotoxicity; Desymmetrization; Barton-Mccombie Reaction; Wittig Homologation
ID Code:59552
Deposited On:07 Sep 2011 05:58
Last Modified:07 Sep 2011 05:58

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