Association of ADAM33 gene polymorphisms with asthma in Indian children

Awasthi, Shally ; Tripathi, Priya ; Ganesh, Subramaniam ; Husain, Nuzhat (2011) Association of ADAM33 gene polymorphisms with asthma in Indian children Journal of Human Genetics, 56 (3). pp. 188-195. ISSN 1434-5161

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Asthma is the most common chronic disorder in childhood, and asthma exacerbation is an important cause of childhood morbidity and hospitalization. In the present study, the relationship between single-nucleotide polymorphisms (SNPs) of the ADAM33 gene and asthma in Indian children has been examined using a case-control study. Five SNPs of the ADAM33 gene, F+1(rs511898) G/A, S2 (rs528557) G/C, ST+4 (rs44707) A/C, ST+5 (rs597980) C/T and V4 (rs2787094) C/G, were analyzed in 211 asthma cases and 137 controls aged 1-15 years using the PCR-restriction fragment length polymorphism method. Data were statistically analyzed using the Χ2-test and logistic regression model. Haplotype estimation and linkage disequilibrium were conducted using the expectation-maximization algorithm. The genotypes and allele frequencies of SNPs S2 and ST+5 of the ADAM33 gene were significantly associated with asthma risk (P=0.020-<0.001), whereas F+1, ST+4, V4 homozygous mutant genotypes and mutant alleles were significantly associated with increased asthma risk (P=0.031-<0.001). A positive association was also found with haplotypes AGCCT, GGACT and AGCCC (P=<0.001, odds ratio (OR)=6.10-6.50), whereas ACAGT, AGCGC, AGCGT, GCAGC and GCCGT showed protective association with asthma (P=0.019-0.000, OR=0.50-0.20). Taken together, out results suggest that ADAM33 gene polymorphisms may modify individual susceptibility to develop childhood asthma in the Indian population.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Childhood Asthma; Haplotypes; Single-nucleotide Polymorphisms (SNPs)
ID Code:59482
Deposited On:06 Sep 2011 06:05
Last Modified:06 Sep 2011 06:05

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