Six-monthly De-worming in infants to study effects on growth

Awasthi, Shally ; Pande, Vinod Kumar (2001) Six-monthly De-worming in infants to study effects on growth Indian Journal of Pediatrics, 68 (9). pp. 823-827. ISSN 0019-5456

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Objective: The study was conducted to assess the effectiveness of six monthly albendazole (ABZ) for improving the weight and height of preschool children when initia ted at 0.5-1 year of age in populations with a high transmission rate of intestinal roundworm,Ascaris lumbricoides. It was a cluster randomized trial in the urban slums of Lucknow, North India.Methods: Control children received 2 ml (1 ml to infants) of Vitamin A every six month whereas those in the ABZ areas received, in addition, 400 mg of ABZ suspension (Zentel, SKB) every six month. Sixty-three and sixty-one slum areas were randomized to albendazole (ABZ) or to control groups, respectively. Children aged 0.5-1 year were recruited in April 1996 and followed up for 1.5 years. Of 1022 children recruited from control and 988 from ABZ areas, the loss to follow-up at 1.5 year was 15.6% and 14.6% respectively. Mean (±SE) weight gain in Kg in control versus ABZ areas was 3.04 (0.03) versus 3.22 (0.03), (p=0.01).Results: After controlling for the presence of weight-for age z-score <-2.00 at enrollment in the ordinary least square's regression model, the extra weight gain in 1.5 years in those who received ABZ plus vitamin A was 0.13 Kg (95% Cl:0.004 to 0.26 Kg., p value=0.043) when compared to those who received only vitamin A; underweight children at enrollment benefiting more than the normal ones.Conclusion: It was concluded that there was an improvement in weight with six monthly ABZ over 1.5 years. However, a much larger trial would be needed to determine whether there is any net effect of improvement in weight on under five mortality rate.

Item Type:Article
Source:Copyright of this article belongs to K.C. Chaudhuri Foundation.
Keywords:De-worming; Albendazole; Growth; Underweight; Infant
ID Code:59466
Deposited On:06 Sep 2011 05:57
Last Modified:18 May 2016 10:02

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