Yadav, J. S. ; Ramesh Reddy, A. ; Venkat Narsaiah, A. ; Reddy, B. V. S. (2007) An efficient protocol for regioselective ring opening of epoxides using samarium triflate: synthesis of propranolol, atenolol and RO363 Journal of Molecular Catalysis A: Chemical, 261 (2). pp. 207-212. ISSN 1381-1169
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.molcata.2006.07.059
Abstract
The oxiranes undergo rapid ring opening reaction with amines catalyzed by samarium triflate under mild reaction conditions. The reactions were carried out at below room temperature to afford the corresponding β-amino alcohols in excellent yields and high regioselectivity. This protocol has been applied for the synthesis of various β-blockers.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Epoxides; Amines; Samarium Triflate; 2-amino Alcohols; β-blockers |
| ID Code: | 58902 |
| Deposited On: | 02 Sep 2011 03:24 |
| Last Modified: | 02 Sep 2011 03:24 |
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