Yadav, J. S. ; Reddy, B. V. S. ; Muralikrishna Reddy, P. ; Srinivas, Ch. (2002) Zinc-mediated Barbier reactions of pyrrole and indoles: a new method for the alkylation of pyrrole and indoles Tetrahedron Letters, 43 (29). pp. 5185-5187. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4039(02)00971-1
Abstract
Pyrrole and indoles react smoothly with alkyl halides such as allyl bromide, prenyl bromide, crotyl bromide and propargyl bromide in the presence of zinc metal in THF to afford the corresponding 3- and 2-alkyl pyrrole and 3-alkyl indole derivatives in good yields with high regioselectivity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Organozinc Reagents; Barbier Reaction; C-alkylation of Heterocycles |
| ID Code: | 58880 |
| Deposited On: | 02 Sep 2011 03:14 |
| Last Modified: | 02 Sep 2011 03:14 |
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