Yadav, J. S. ; Mishra, Rajesh Kumar (2002) First total synthesis of strongylodiol A Tetrahedron Letters, 43 (9). pp. 1739-1741. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4039(02)00066-7
Abstract
A new cytotoxic long-chain acetylenic alcohol (R)-strongylodiol A, originally isolated from an Okinawan marine sponge of the genus Strongylophora, has been synthesized for the first time using commercially available 1,10-decanediol. The key step of this process involves the selective introduction of the (R)-configuration at C-6 which was achieved by β-elimination of epoxychlorides. Strongylodiol A was synthesized efficiently in a highly stereoselective manner starting from 1,10-decanediol.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Strongylodiol; Chiral Carbinol; 2,3-epoxychloride; Cadiot-Chodkiewiez Cross Coupling |
| ID Code: | 58809 |
| Deposited On: | 02 Sep 2011 03:13 |
| Last Modified: | 02 Sep 2011 03:13 |
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