Three-component synthesis of 2-aryl-4-arylthio-tetrahydro-2H-pyrans via the Prins-cyclization

Yadav, J. S. ; Subba Reddy, B. V. ; Jayasudhan Reddy, Y. ; Sivasankar Reddy, N. (2009) Three-component synthesis of 2-aryl-4-arylthio-tetrahydro-2H-pyrans via the Prins-cyclization Tetrahedron Letters, 50 (24). pp. 2877-2880. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2009.03.176

Abstract

A three-component coupling of aldehyde, homoallylic alcohol and aryl thiol has been achieved in the presence of trifluoroacetic acid in dichloromethane at room temperature to produce 4-arylthiotetrahydropyrans in good yields with all cis-selectivity. This method is simple, selective and convenient for introducing a thiol group on a tetrahydropyran ring.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Prins-cyclization; Three-component Reaction; 4-arylthiotetrahydropyrans
ID Code:58752
Deposited On:02 Sep 2011 03:33
Last Modified:02 Sep 2011 03:33

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