Effect of O(2')-methylation on the stability of polynucleotide helices

Yathindra, N. ; Sundaralingam, M. (1979) Effect of O(2')-methylation on the stability of polynucleotide helices Biopolymers, 18 (11). pp. 2721-2731. ISSN 0006-3525

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/bip.197...

Related URL: http://dx.doi.org/10.1002/bip.1979.360181106

Abstract

The effect of ribose(O2')-methylation on the stability of (O2')-methylated polyribonucleotide helices has been studied by conformational energy calculations. The preferred orientation of the methyl group is found to further stabilize the helical phosphodiester conformation (g-,g-) due to the enhanced short-range interactions arising between the methyl groups and the adjacent ribose moieties. The experimentally observed increase in melting temperature of (O2')-alkylated polyribonucleotides is thus attributable to the enhanced stability of the helical backbone conformation.

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