Ion pairs in alpha helices

Sundaralingam, M. ; Sekharudu, Y. C. ; Yathindra, N. ; Ravichandran, V. (1987) Ion pairs in alpha helices Proteins Structure Function and Bioinformatics, 2 (1). pp. 64-71. ISSN 1097-0134

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A survey of 47 globular proteins was made to determine the probability of occurrence of ion pairs separated by 1, 2, 3,... and 8 residues in the alpha helices. As a control, the probability of occurrence of like charged pairs was also determined. The survey showed that ion pairs of the type i, i±3 and i, i±4 are the most predominant. Such a preference was not observed for like charged pairs. The observed frequency of ion pairs is significantly greater than their expected frequency. The normalized frequencies of occurrence of the ion pairs were also found to increase generally with the helix length. These results indicate that the ion pairs may contribute to the stability of solvent-exposed alpha helices. Since the stabilization of protein secondary structure, these results may throw light on the mechanism of protein folding.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Intrahelical Ion Pairs; Frequency of Ion Pairs in Exposed Helices; Alpha-helix Stabilization; Protein Tertiary Structure Stabilization; Protein-folding Pathway
ID Code:58686
Deposited On:02 Sep 2011 03:48
Last Modified:02 Sep 2011 03:48

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