Hybrid sugars as glycosidase inhibitors en route to 2-deoxy-2-amino C-glycosyl amino acids

Jayakanthan, K. ; Vankar, Yashwant D. (2006) Hybrid sugars as glycosidase inhibitors en route to 2-deoxy-2-amino C-glycosyl amino acids Tetrahedron Letters, 47 (49). pp. 8667-8671. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2006.10.024

Abstract

Sugar-azasugar hybrid molecules made up of D-galactose with nojirimycin-δ-lactam and pyrrolidine analogues are synthesized using intramolecular cyclization as a key step from 2-nitro galactal and found to be glycosidase inhibitors. Further, some of the intermediate compounds are converted into 2-deoxy-2-amino C-glycosyl glycines and C-glycosyl alanines.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:58297
Deposited On:31 Aug 2011 06:39
Last Modified:31 Aug 2011 06:39

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