Signalling mechanisms in Mycobacteria

Chakraborti, Pradip K. ; Matange, Nishad ; Nandicoori, Vinay K. ; Singh, Yogendra ; Tyagi, Jaya S. ; Visweswariah, Sandhya S. (2011) Signalling mechanisms in Mycobacteria Tuberculosis, 91 (5). pp. 432-440. ISSN 1472-9792

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The importance of inter- and intracellular signal transduction in all forms of life cannot be underestimated. A large number of genes dedicated to cellular signalling are found in almost all sequenced genomes, and Mycobacteria are no exception. What appears to be interesting in Mycobacteria is that well characterized signalling mechanisms used by bacteria, such as the histidine-aspartate phosphorelay seen in two-component systems, are found alongside signalling components that closely mimic those seen in higher eukaryotes. This review will describe the important contribution made by researchers in India towards the identification and characterization of proteins involved in two-component signalling, protein phosphorylation and cyclic nucleotide metabolism.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Cyclic AMP; DevR; DevS; Protein kinase; Phosphodiesterase
ID Code:57544
Deposited On:27 Aug 2011 12:20
Last Modified:13 Jul 2012 13:39

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