Comprehensive examination of mesophases formed by DMPC and DHPC mixtures

Harroun, Thad A. ; Koslowsky, Martin ; Nieh, Mu-Ping ; de Lannoy, Charles-François ; Raghunathan, V. A. ; Katsaras, John (2005) Comprehensive examination of mesophases formed by DMPC and DHPC mixtures Langmuir, 21 (12). pp. 5356-5361. ISSN 0743-7463

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Mixtures of long- and short-chain phospholipids, specifically 14:0 and 6:0 phosphatidylcholines (DMPC and DHPC), have been used successfully in NMR studies as magnetically alignable substrates for membrane-associated proteins. However, recent publications have shown that the phase behavior of these mixtures is much more complex than originally thought. Using polarized light microscopy and small-angle neutron scattering, phase diagrams of DMPC/DHPC mixtures at molar ratios of 2, 3.2, and 5 have been determined. Generally, at temperatures below the main-chain melting transition of DMPC (TM = 23°C), an isotropic phase of disklike micelles is found. At high temperatures (T > 50°C), a lamellar phase consisting of either multilamellar vesicles (MLV) or extended lamellae is formed, which at low lipid concentrations (e.g., MLV) coexists with an excess of water. At intermediate temperatures and lipid concentrations, a chiral nematic phase made up of wormlike micelles was observed.

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Source:Copyright of this article belongs to American Chemical Society.
ID Code:57184
Deposited On:26 Aug 2011 02:27
Last Modified:29 Nov 2011 10:39

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