HLA antigens in multiple sclerosis amongst Indians

Wadia, N. H. ; Trikannad, V. S. ; Krishnaswamy, P. R. (1981) HLA antigens in multiple sclerosis amongst Indians Journal of Neurology, Neurosurgery & Psychiatry, 44 (9). pp. 849-851. ISSN 0022-3050

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Official URL: http://jnnp.bmj.com/content/44/9/849.abstract

Related URL: http://dx.doi.org/10.1136/jnnp.44.9.849


The infrequency of multiple sclerosis in India may have genetic implications. We found (a) the HLA-A3 and HLA-B7 haplotypes amongst Indians to be lower than those reported in Caucasians, (b) no excess of HLA-A3 and HLA-B7 amongst our 27 multiple sclerosis patients compared to 330 controls; instead it was the reverse, (c) HLA-B12 as high as 74% in the "clinically definite" cases, against only 9% in controls, (d) a significant relative risk of MS amongst Indians with HLA-B12 haplotype. Attention is drawn to th higher incidence of MS amongst the small Parsee community and the high association of HLA-B12 in these patients.

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