Association of HLA-B12 with multiple sclerosis in India

Wadia, N. H. ; Trikannad, V. S. ; Krishnaswamy, P. R. (1980) Association of HLA-B12 with multiple sclerosis in India Tissue Antigens, 15 (1). pp. 90-93. ISSN 0001-2815

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...

Related URL: http://dx.doi.org/10.1111/j.1399-0039.1980.tb00891.x

Abstract

In Indian patients with Multiple Sclerosis it was observed, upon testing for serum determinable histocompatibility antigens, that HLA-B12 antigen was present in excess (77.7%), in comparison with normal controls (13.8%). In fact, in the sub-group of 'clinically definite' patients, the B12 antigen excess was remarkable (84%). These preliminary findings seem to point to a different immunogenetic profile of Indian MS patients in comparison with Western and Japanese series. Relevant published information relating to the HLA-B12 alleles in disease processes is discussed in order to provide a basis for further work.

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