Temporal bone of monkey in experimental tuberculous meningitis

Abstract

This experimental study was done by challenging monkeys with intracisternal injection of mycopacterium tuberculosis var Hominis in B.C.G. vaccinated and drug protected monkeys. It was concluded that in monkeys this intracisternal injection of tubercular organism causes basal meningitis involving the dural surface of petrous temporal bone. The inner ear and eighth nerve did not show any morphological evidence of tubercular involvement. The granulation removed such lesions though positive for culture of the mycobacterium, does not show caseation or Langhan's type of giant cells.