Ocular structure in vitamin a deficiency in the monkey

Ramalingaswami, V. ; Leach, E. H. ; Sriramachari, S. (1955) Ocular structure in vitamin a deficiency in the monkey Experimental Physiology, 40 . pp. 337-347. ISSN 0958-0670

Full text not available from this repository.

Official URL: http://ep.physoc.org/content/40/4/337.short

Abstract

1. The role of vitamin A in the metabolism of cone cells of the retina was investigated, from the morphological angle, by studying their structure in induced deficiency of vitamin A in three monkeys. 2. Unequivocal signs of structural damage were observed in the cone and rod cells of the deficient animals, which also showed the classical signs of vitamin A deficiency in other organs. 3. In vitamin A deficiency, damage to the visual cell layer of the retina occurred in one monkey in the absence of corneal involvement. This finding suggests that chronic vitamin A deficiency in the community may lead to progressive damage to the visual cells in a much larger number of persons than the incidence figures for keratomalacia indicate. 4. Degeneration of pigment epithelium was present in retinal sections from all the deficient animals. The possible role of the pigment epithelium in the pathogenesis of the visual defect in vitamin A deficiency has been discussed. 5. Degenerative changes were noted in Descemet's endothelium. This damage may contribute to the degeneration of the corneal epithelium.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:56807
Deposited On:25 Aug 2011 09:51
Last Modified:25 Aug 2011 09:51

Repository Staff Only: item control page