Prediction and comparison of the secondary structure of legume lectins

Joginadha Swamy, M. ; Venkata Krishna Sastry, M. ; Surolia, Avadhesha (1985) Prediction and comparison of the secondary structure of legume lectins Journal of Biosciences, 9 (3-4). pp. 203-212. ISSN 0250-5991

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Secondary structure prediction for the 4 legume lectins: Concanavalin A, soybean agglutinin, favabean lectin and lentil lectin, was done by the method of Chou and Fasman. This prediction shows that these four lectins fall into a structurally distinct class of proteins, containing high amounts of β-sheet and β-turns. There is a notable similarity in the gross structure of these proteins; all four of them contain about 40-50% of β-sheet, 35-45 % β-turn and 0-10% of α-helix. When the secondary structure of corresponding residues in each pair of these lectins was compared, there was a striking similarity in the Concanavalin A-soybean agglutinin and favabean lectin-lentil lectin pairs, and considerably less similarity in the other pairs, suggesting that these legume lectins have probably evolved in a divergent manner from a common ancestor. A comparison of the predicted potential β-turn sites also supports the hypothesis of divergent evolution in this class of lectins.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Secondary Structure Prediction; Legume Lectins; Divergent Evolution; β-turns
ID Code:56682
Deposited On:25 Aug 2011 10:23
Last Modified:18 May 2016 08:24

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