Lakshmi Swarna Mukhi, P. ; Kumar Sharma, S. ; Kapoor, M. ; Surolia, N. ; Surolia, A. ; Suguna, K. (2004) Crystallization and preliminary crystallographic analysis of β-hydroxyacyl ACP dehydratase (FabZ) from Plasmodium falciparum Acta Crystallographica Section D, 60 . pp. 120-121. ISSN 0907-4449
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Official URL: http://scripts.iucr.org/cgi-bin/paper?za5011
Related URL: http://dx.doi.org/10.1107/S0907444903022327
Abstract
The malarial parasite Plasmodium falciparum synthesizes fatty acids by the type II mechanism. In this cycle, the dehydration of the β-hydroxyacyl acyl carrier protein is catalyzed by FabZ. Purified FabZ has been crystallized using the hanging-drop vapour-diffusion and microbatch techniques. The crystals are orthorhombic, with space group I222 or I212121 and unit-cell parameters a=71.78, b=81.99, c=97.49 Å. A complete data set to a resolution of 2.5 Å has been collected under cryoconditions (100 K) using a MAR imaging-plate detector system mounted on a rotating-anode X-ray generator.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to International Union of Crystallography. |
| Keywords: | FabZ; FAS II; Dehydratases; Plasmodium falciparum |
| ID Code: | 56673 |
| Deposited On: | 25 Aug 2011 10:25 |
| Last Modified: | 03 Oct 2011 14:04 |
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