Clavel, Caroline ; Canales, Angeles ; Gupta, Garima ; Ignacio Santos, J. ; Javier Cañada, F. ; Penadès, Soledad ; Surolia, Avadesha ; Jimènez-Barbero, Jesùs (2007) NMR studies on the conformation of oligomannosides and their interaction with banana lectin Glycoconjugate Journal, 24 (8). pp. 449-464. ISSN 0282-0080
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Official URL: http://www.springerlink.com/content/13167u51m2212u...
Related URL: http://dx.doi.org/10.1007/s10719-007-9037-0
Abstract
The conformational and dynamic behaviour of three mannose containing oligosaccharides, a tetrasaccharide with α1→2, and α1→3, and a penta and a heptasaccharide with α1→2, α1→3, and α1→6 linkages has been evaluated by molecular mechanics and dynamics simulations and NMR spectroscopical methods. It is found that they display a fair amount of conformational freedom, with one major and one minor conformation per glycosidic linkage. The evaluation of their recognition by banana lectin has also been performed by STD NMR methods and a preliminary view of their putative interaction mode has been carried out by means of docking procedures.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer. |
| Keywords: | Mannose Oligosaccharides; NMR; Molecular Dynamics; Banana Lectin; Molecular Recognition |
| ID Code: | 56662 |
| Deposited On: | 25 Aug 2011 10:25 |
| Last Modified: | 25 Aug 2011 10:25 |
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