Ramya, T. N. C. ; Surolia, Namita ; Surolia, Avadhesha (2006) Polyamine synthesis and salvage pathways in the malaria parasite Plasmodium falciparum Biochemical and Biophysical Research Communications, 348 (2). pp. 579-584. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bbrc.2006.07.127
Abstract
We demonstrate, for the first time, a functional polyamine biosynthetic pathway in the malaria parasite Plasmodium falciparum that culminates in the synthesis of spermine. Additionally, we also report putrescine and spermidine salvage in the malaria parasite. Putrescine and spermidine transport in P. falciparum infected red blood cells is a highly specific, carrier mediated and active process, mediated by new transporters that differ from the transporters of uninfected red blood cells in their kinetic parameters, Vmax and km, as well as in their activation energy.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Polyamine Biosynthesis; Polyamine Transport; Plasmodium falciparum; Putrescine; Spermidine; Spermine |
| ID Code: | 56440 |
| Deposited On: | 24 Aug 2011 11:32 |
| Last Modified: | 03 Oct 2011 14:07 |
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