c-myc Oncogene expression and cell proliferation in mixed oligo-astrocytoma

Banerjee, Moinak ; Dinda, Amit K. ; Sinha, Subrata ; Sarkar, Chitra ; Mathur, Meera (1996) c-myc Oncogene expression and cell proliferation in mixed oligo-astrocytoma International Journal of Cancer, 65 (6). pp. 730-733. ISSN 0020-7136

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1...

Related URL: http://dx.doi.org/10.1002/(SICI)1097-0215(19960315)65:6<730::AID-IJC3>3.0.CO;2-#

Abstract

Mixed gliomas (oligo-astrocytomas) are brain tumours with an admixture of 2 different cell populations: astrocytes and oligodendroglia. On the basis of histological features and behaviour, these tumours are classified as low-grade mixed gliomas (MG) and malignant mixed gliomas (MMG). We have studied the relationship between c-myc protein expression and cellular proliferation in this class of tumours. Using antibody c-33 for c-myc and PC-10 for the proliferating cell nuclear antigen (PCNA), immunohistochemistry was performed on 14 MG and 9 MMG. PCNA was increased in MMG as compared to MG in both astrocytic and oligodendroglial areas. However, more c-myc-positive cells were seen only in the astrocytic areas of MMG. Analysis of the relationship of c-myc and PCNA suggests that the correlation of c-myc with cellular proliferation is dependent on tissue type and differentiation status.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:56365
Deposited On:23 Aug 2011 11:30
Last Modified:15 Jul 2012 09:47

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