Oligodendroglial tumors: an immunohistochemical and electron microscopic study

Sarkar, Chitra ; Roy, Subimal ; Tandon, P. N. (1988) Oligodendroglial tumors: an immunohistochemical and electron microscopic study Cancer, 61 (9). pp. 1862-1866. ISSN 0008-543X

Full text not available from this repository.

Official URL: http://onlinelibrary.wiley.com/doi/10.1002/1097-01...

Related URL: http://dx.doi.org/10.1002/1097-0142(19880501)61:9<1862::AID-CNCR2820610923>3.0.CO;2-X


Fifty-five cases of oligodendrogliomas and mixed oligoastrocytomas were evaluated using immunohistochemical (IH) study for glial fibrillary acidic protein (GFAP) and electron microscopic (EM) study. Most of the tumors in both of these groups showed many neoplastic oligodendroglial cells with GFAP-positive staining in their cytoplasm by IH study. By EM study too, many tumor cells showing features of oligodendroglial cells contained intermediate filaments. Our observations suggested the presence of a transitional form of cells in these tumors. The current study supports the contention that both oligodendrogliomas and oligoastrocytomas arise from a common progenitor cell capable of differentiation into both oligodendrocyte and astrocyte. The nature and degree of differentiation depends probably on gene expression and/or some microenvironmental factors.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:56360
Deposited On:23 Aug 2011 11:29
Last Modified:12 Jul 2012 10:19

Repository Staff Only: item control page