Assortative mixing in protein contact networks and protein folding kinetics

Bagler, Ganesh ; Sinha, Somdatta (2007) Assortative mixing in protein contact networks and protein folding kinetics Bioinformatics, 23 (14). pp. 1760-1767. ISSN 1367-4803

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Motivation: Starting from linear chains of amino acids, the spontaneous folding of proteins into their elaborate 3D structures is one of the remarkable examples of biological self-organization. We investigated native state structures of 30 single-domain, two-state proteins, from complex networks perspective, to understand the role of topological parameters in proteins' folding kinetics, at two length scales - as 'Protein Contact Networks (PCNs)' and their corresponding 'Long-range Interaction Networks (LINs)' constructed by ignoring the short-range interactions. Results: Our results show that, both PCNs and LINs exhibit the exceptional topological property of 'assortative mixing' that is absent in all other biological and technological networks studied so far. We show that the degree distribution of these contact networks is partly responsible for the observed assortativity. The coefficient of assortativity also shows a positive correlation with the rate of protein folding at both short- and long-contact scale, whereas, the clustering coefficients of only the LINs exhibit a negative correlation. The results indicate that the general topological parameters of these naturally evolved protein networks can effectively represent the structural and functional properties required for fast information transfer among the residues facilitating biochemical/kinetic functions, such as, allostery, stability and the rate of folding.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
ID Code:56191
Deposited On:23 Aug 2011 12:02
Last Modified:18 May 2016 08:07

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